Anthropometric measures were height, sitting height, arm span, length of arm, hand, and foot, biacromial and bi-iliac diameter, hip, waist, and head circumference as well as 2D:4D digit ratio. Since there is usually one additional chromosome in Klinefelter syndrome, it is considered as a trisomy while tuner syndrome is regarded as a monosomy because one chromosome is missing in the affected individuals. Adolesc Med State Art Rev. INCIDENCE : 1 in 2000 live male births KARYOTYPE: 82% have classical 47,XXY 15% mosaics , 46XY/47,XXY Remaining polysomic individuals 13. Often, symptoms are subtle and subjects do not realize they are affected. Mosaic Turner syndrome is when some, but not all of the cells of the individual having Turner’s syndrome have an unusual combination of sex chromosomes. Similarities Between Klinefelter and Turner Syndrome Klinefelter syndrome is a genetic condition affecting males, and it often isn't diagnosed until adulthood.Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. There is a lot of variation in this regard, with some individuals having cells that are 45,X but in other cases they may even have some cells that are XY and some that are 45,X. … Klinefelter's syndrome (KS) affects one in 600 men and Turner's syndrome (TS), one in 2500 women. The early diagnosis of them can be helpful in treating the complications arising from the underlying disease. Turner syndrome is the dysgenesis in the female gonads, while Klinefelter syndrome is the male hypogonadism. In the case of Klinefelter syndrome, the male has 2 X chromosomes and 1 Y chromosome (Figure 1). Turner syndrome is the complete or partial monosomy of the X chromosome, which is characterized primarily by the hypogonadism in phenotypic females. Gene mutation and chromosomal mutations introduce alterations to the genetic material of a particular organism. The main difference between Turner Syndrome and Klinefelter Syndrome is that Turner Syndrome is the change in the genetic chromosomes in females while a Klinefelter Syndrome is a change in ancestral chromosomes in men. The main difference between Klinefelter and Turner Syndrome is that Klinefelter syndrome is a trisomy whereas Turner syndrome is a monosomy. Klinefelter syndrome is defined as the male hypogonadism that occurs when there are two or more X chromosomes and two or more Y chromosomes. Definition. Turner syndrome is related to the X chromosome, which is one of the two sex chromosomes.People typically have two sex chromosomes in each cell: females have two X chromosomes, while males have one X chromosome and one Y chromosome.Turner syndrome results when one normal X chromosome is present in a female's cells and the other sex chromosome is missing or structurally altered. All measurements were performed by the same observer (AS). Overview and Key Difference 1. The main difference between Klinefelter and Turner syndrome is that Klinefelter is a condition of trisomy in which one extra X chromosome is present in the genome of the person and Turner syndrome is a condition of monosomy in which one X chromosome is lacking in the genome of the affected person. Klinefelter syndrome is a trisomy, and the most frequently associated karyotype is 47, XXY. “45,X” (CC BY-SA 3.0) via Commons Wikimedia. Both these conditions are cytogenic disorders involving the sex chromosomes. Down syndrome, Turner syndrome, and Klinefelter syndrome constitute the most common chromosomal abnormalities encountered by primary care physicians. Turner syndrome and Klinefelter syndrome are similar in that they both affect the sexual chromosomes and the development of the gonads, or reproductive organs. Answered on Jul 4, 2018. Filed Under: Diseases Tagged With: Compare Klinefelter and Turner Syndrome, Klinefelter and Turner Syndrome Differences, Klinefelter and Turner Syndrome Relationship, Klinefelter Syndrome, Klinefelter Syndrome Clinical Features, Klinefelter Syndrome Definition, Klinefelter vs Turner Syndrome, Turner Syndrome, Turner Syndrome Clinical Features, Turner Syndrome Definition. 6. Both males with Klinefelter syndrome and women with Triple X syndrome have an extra X chromosome; however women with Triple X syndrome do not also have a "Y" chromosome. Top 10 blogs in 2020 for remote teaching and learning; Dec. 11, 2020 In Kallmann syndrome the levels of LH and FSH are much lower than normal, known as hypogonadotropism. Klinefelter syndrome is caused when a male baby is born with more than required or extra X chromosomes. Patients having the Klinefelter syndrome have an increased risk of developing breast cancers, extragonadal germ cell tumors and autoimmune diseases such as SLE. Print. Your email address will not be published. XO; genetically sexless. As previously mentioned, in a majority of the cases the Klinefelter syndrome is associated with the 47, XXY karyotype. Down syndrome typically is recognized at birth, Turner syndrome often is not recognized until adolescence,and many men with Klinefelter syndrome are never diagnosed. Individuals with Klinefelter syndrome have two X chromosomes but also have one Y chromosome. 2. PMID: 26999880 [PubMed - indexed for MEDLINE] It is due to monosomy (2n-1). 5. The two genetic disorders discussed here are extremely common conditions. Sex Sterile Female Sterile Male 3. 2. What is Klinefelter Syndrome In Klinefelter syndrome you have partial to normal puberty but the testicles do not function correctly. Turner syndrome is also known as monosomy of the X chromosome. The early diagnosis of them can be helpful in treating the complications arising from the underlying disease. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue. “Human chromosomesXXY01” By User:Nami-ja – Own work (Public Domain) via Commons Wikimedia Turner syndrome causes female hypogonadism. Kingery SE, Wintergerst KA. Turner syndrome is the genetic abnormality of females while Klinefelter syndrome is a genetic abnormality of men. KLINEFELTER’S SYNDROME 12. 3. Monosomy of sex chromosome (2n-1), in this only one X chromosome, is present. Down syndrome or Mongolism is autosomal disorder and turner and klinefelter's syndrome are sex chromosomal disorder caused due to non disjunction. Compare the Difference Between Similar Terms. Klinefelter syndrome vs Turner syndrome. Side by Side Comparison – Klinefelter vs Turner Syndrome in Tabular Form It is due to trisomy (2n+1) of sex chromosome. Both conditions can cause some behavioral concerns, learning difficulties, and taller stature. Turner Syndrome and Klinefelter Syndrome. These can be explained by saying that both the terms are problems related to the sex chromosomes, as in the earlier one there is lacking of one of the sex chromosomes and so-called as monosomy (2n-1), while the latter consist of the extra sex chromosome and so-called as trisomy (2n+1). Blog. This condition is far less common than Klinefelter syndrome, affecting only one in 2,000 to 2,500 female births. All rights reserved. Turner syndrome is a monosomy, and it is most often associated with the karyotype 45, X. Klinefelter syndrome causes male hypogonadism. Turner syndrome is the complete or partial monosomy of the X chromosome which is characterized primarily by the hypogonadism in phenotypic females. ADVERTISEMENTS: Some of the major Differences between Turner’s syndrome and Klinefelter’s Syndrome are as follows: Character Turner’s Syndrome Klinefelter’s Syndrome 1. Terms of Use and Privacy Policy: Legal. Klinefelter syndrome (KS), also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. Turner syndrome and the Klinefelter syndrome are the rare cases where the earlier one occurs in 1 out of 2500 phenotypic female, while the latter one occurs in 1 in 1100 births. How to increase brand awareness through consistency; Dec. 11, 2020. These 2 diseases are the most sex chromosome disorders characterized by one extra X in the SK male (47XXY) and the loss of an X in the girls with ST (45 X). After the merger, the newly formed three individual XXY sex chromosomes. Raven magnimeter and Harpenden anthropometer were u… See each disorder's website. Privacy. Individuals with Turner syndrome have an X chromosome but no Y chromosome. It is commonly treated with estrogen, growth hormones and replacement therapy. 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Since the genes that produce "maleness" are on the Y chromosomes, these individuals will always be female. Additionally, Turner syndrome and Klinefelter syndrome present similar symptoms. In this condition, there is missin… Turner and Klinefelter syndromes are common chromosomal disorders involving X chromosome.1,2 Turner syndrome is characterized by partial or complete absence of one X chro-mosome in women,1 and it occurs in 1:2,000 to 1:5,000 live female births.3 Klinefelter syndrome results from two or more X chromosomes in men.4 Klinefelter syndrome is one Chromosomal Mutation: Klinefelter syndrome, Turner syndrome, and Down syndrome are caused by chromosomal mutations. This condition is typically diagnosed after puberty because the testicular abnormality does not develop before the early puberty. Klinefelter syndrome is defined as the male hypogonadism that occurs when there are two or more X chromosomes and two or more Y chromosomes. Karyotype of the Turner syndrome is monosomy of sex chromosome. @media (max-width: 1171px) { .sidead300 { margin-left: -20px; } } 2015 Aug;26(2):411-27. Turner syndrome leads to various developmental problems and people with this syndrome are at risk of many diseases. Klinefelter syndrome is a genetic condition that results when a boy is born with an extra copy of the X chromosome. The X chromosome carries more genetic information than is present on the Y chromosome. Turner Syndrome In female infants, instead of an extra chromosome, Turner syndrome, named for the physician who discovered it in 1938, is caused by a lack of, or damage to, one of the pair of X chromosomes. This is the key difference between Klinefelter and Turner Syndrome. His experience in communicating with the general public during his medical practice has enabled him to describe facts that a layman has to know about a particular disorder in a concise and understandable manner. Turner Syndrome occurs in a female fetus with an incomplete or missing X Chromosome, with characteristic features, Non-Verbal Learning Disabilities, short stature & infertility. This is because of the absence of an entire X chromosome, structural damages to the X chromosomes or the presence of mosaics. KLINEFELTER SYNDROME It is the state of male hypogonadism due to 2 or more X chromosome with 1 or more y chromosome. Genotype 44 + X0 44 + XXY 2. Turner syndrome (TS) and Klinefelter syndrome (KS) are two of the most common sex chromosome aneuploidies (Berglund et al., 2019).The prevalence of TS is approximately 1 in 2000 to 1 in 4000 among women and is characterized by a chromosomal disorder affecting phenotypically female individuals harboring one intact X chromosome and complete absence [X … Summary. In both Turner syndrome (TS) and Klinefelter syndrome (KS) copy number aberrations of the X chromosome lead to various developmental symptoms. We report a comparative analysis of TS vs. KS regarding differences at the genomic network level measured in primary samples by analyzing gene expression, DNA methylation, and chromatin conformation. Klinefelter syndrome is defined as the male hypogonadism that occurs when there are two or more X chromosomes and two or more Y chromosomes. Adolesc Med State Art Rev. The primary features are infertility and small poorly functioning testicles. Trisomy of sex chromosome (2n+1), in this XXY chromosome, are present in males. Turner syndrome, a condition that affects only females, results when one of the X chromosomes (sex chromosomes) is missing or partially missing. 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With Turner's Syndrome, the females actually have 1 less chromosome, not an extra one or sometimes only part of the X chromosome is missing. Testosterone therapy and hormone therapy. Turner syndrome can cause a variety of medical and developmental problems, including short height, failure of the ovaries to develop and heart defects.Turner syndrome may be diagnosed before birth (prenatally), during infancy or in early childhood. What is Turner Syndrome Undeveloped testes, sparse … The presence of a Y chromosome is necessary for an individual to be male. 1 INTRODUCTION. 3 doctors agree. Hypogonadism – Plasma gonadotropin concentration (especially FSH concentration) is elevated. The main difference between Klinefelter and Turner Syndrome is that Klinefelter syndrome is a trisomy whereas Turner syndrome is a monosomy. Klinefelter syndrome. Sex Characters Undeveloped ovaries and breasts, small uterus, absence of menstruation, absence of sex chromatin, narrow hips. In the case of Turner’s syndrome have been X chromosome missing in the sex cell, or lost after the merger of male and female sex cells, but the reason why this happens is unknown. When a girl is born with the different genetic condition than the normal one, it is called as Turner syndrome, in this, there is the loss of one of the sex chromosome (XO instead of XX). Advertisement - Continue Reading Below. 1.Kumar, Vinay, Stanley Leonard Robbins, Ramzi S. Cotran, Abul K. Abbas, and Nelson Fausto. Robbins and Cotran pathologic basis of disease. Lack of secondary male sexual characteristics, No mental retardation but the IQ is slightly less than that of the normal population, Most severely affected individuals suffer from edema of the dorsum of hand and foot during infancy, Swelling of the nape of the neck can also be seen occasionally in the affected infants, Streak ovaries, infertility, and amenorrhea. Philadelphia, Pa: Elsevier Saunders, 2010. Turner syndrome affects the development of the ovaries, while Klinefelter syndrome affects the development of the testes. This syndrome is found in 1 out of 1000 males. 4. The main difference between Klinefelter and Turner syndrome is that Klinefelter is a condition of trisomy in which one extra X chromosome is present in the genome of the person and Turner syndrome is a condition of monosomy in which one X chromosome is lacking in the genome of the affected person.There are many differences between Klinefelter syndrome and Turner syndrome although both … Turner syndrome is the complete or partial monosomy of the X chromosome which is characterized primarily by the hypogonadism in phenotypic females. (adsbygoogle = window.adsbygoogle || []).push({}); Copyright © 2010-2018 Difference Between. Conversely, if Klinefelter syndrome obtain gametes (sperm or egg) two sex chromosomes. Gene mutations are the alterations of the nucleotide sequence of a gene. Conclusion. Dec. 15, 2020. Normally, males have 46 chromosomes with one X and 1 Y chromosome. 1. This is due to the non-disjunction during the meiotic division of germ cells of one of the parents. When a boy is born with the different genetic condition than the normal one, where instead of having normal XY sex chromosome, they have XXY chromosomes, it is termed as Klinefelter syndrome. Genetic Sex: XXY; generally female because of the presence of two X chromosomes. Ranidu is passionate about writing articles on medical topics in general parlance. 1. What is the difference between Klinefelter syndrome and Triple X syndrome? Turner syndrome. The karyotype usually associated with the Turner syndrome is 45, X. In Klinefelter syndrome the levels of LH and FSH are higher than normal, known as hypergonadotropism. Both are trisomies (when someone has three of a certain type of chromosome instead of two), but Klinefelter's is with XXY and Down syndrome is a trisomy of chromosome 21. 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